PMID: 26192331

 

    Legend: Gene, Sites

Title : Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation

Abstract :

1. Sialyltransferases of the mammalian ST8Sia family catalyze oligo- and polysialylation of surface-localized glycoproteins and glycolipids through transfer of sialic acids from CMP-sialic acid to the nonreducing ends of sialic acid acceptors
2. The crystal structure of human ST8SiaIII at 1.85-Å resolution presented here is, to our knowledge, the first solved structure of a polysialyltransferase from any species, and it reveals a cluster of polysialyltransferase-specific structural motifs that collectively provide an extended electropositive surface groove for binding of oligo-polysialic acid chain products
3. The ternary complex of ST8SiaIII with a donor sugar analog and a sulfated glycan acceptor identified with a sialyltransferase glycan array provides insight into the residues involved in substrate binding, specificity and sialyl transfer

Output (sent_index, trigger, protein, sugar, site):

• 1. glycoproteins, , glycoproteins, oligo-, -
• 1. glycoproteins, , glycoproteins, polysialylation, -
• 1. polysialylation, , glycoproteins, -, -

Output(Part-Of) (sent_index, protein, site):

• 2. polysialyltransferase, motifs

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX