PMID: 29992770

 

    Legend: Gene, Sites

Title : Tongue Cancer Patients Can be Distinguished from Healthy Controls by Specific N-Glycopeptides Found in Serum

Abstract :
  1. There are no blood biomarkers to detect early-stage oral cavity squamous cell carcinoma (OSCC) prior to clinical signs
  2. Most OSCC incidence is associated with significant morbidity and poor survival
  3. The authors aimed to use mass-spectrometry (MS) technology to find specific N-glycope N-glycopeptides lly serving as serum biomarkers for preclinical OSCC screening
  4. Serum samples from 14 patients treated for OSCC (stage I or stage IV) with 12 age- and sex-matched controls are collected
  5. Quantitative label-free N-glycoproteomics is performed, with MS/MS analysis of the statistically significantly different N-glycopeptides
  6. Combined with N-glycopeptides rch using web-based software (GlycopeptideID), MS/MS provided detaile GlycopeptideID de information, including g N-glycopeptide ite, glycan com position, and proposed structures
  7. Thirty-eight tryptic N-glycopeptides are identified, having N-glycopeptides cosylation sites representing 14 glycoproteins
  8. OS sites tients, including glycoproteins rs, can be differentiated from healthy controls based on the expression levels of these glycoforms
  9. N-glycopeptides of IgG1 , IgG4 , haptoglo N-glycopeptides errin have stati haptoglobin gnific transferrin nt abundances between cases and controls
  10. The authors are the first to suggest specific N-glycopeptides to serve as potential serum biomarkers to detect preclinica N-glycopeptides nts
  11. These N-glycopeptides are the lead candidates for validation as future diagnostic N-glycopeptides OSCC as early as stage I
Output (sent_index, trigger, protein, sugar, site):
  • 10. N-glycopeptides, , -, -, N-glycopeptides
  • 11. N-glycopeptides, , -, -, N-glycopeptides
  • 3. N-glycopeptides, , -, -, N-glycopeptides
  • 5. N-glycopeptides, , -, -, N-glycopeptides
  • 6. N-glycopeptide, , -, -, N-glycopeptide
  • 7. N-glycopeptides, , -, -, N-glycopeptides
  • 7. N-glycosylation, , -, -, sites
  • 7. glycoproteins, , glycoproteins, -, -
  • 9. N-glycopeptides, , haptoglobin, -, N-glycopeptides
  • 9. N-glycopeptides, , transferrin, -, N-glycopeptides
Output(Part-Of) (sent_index, protein, site):
  • 7. 14, sites
  • 7. glycoproteins, sites
  • 9. haptoglobin, N-glycopeptides
  • 9. transferrin, N-glycopeptides
*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

 

Protein NCBI ID SENTENCE INDEX