Title : The MRC OX-45 antigen of rat leukocytes and endothelium is in a subset of the immunoglobulin superfamily with
CD2 ,
LFA-3 and carcinoembryonic antigens
Abstract :
- The MRC OX-45 cell surface antigen is a glycoprotein of 45 ,000 apparent mol
- wt of rat leukocytes and endothelium
- Antibodies against the antigen inhibit T lymphocyte responses by stimulation of suppression by accessory cells
- We now report the immunochemical characterization of this antigen and its cDNA sequence
- The predicted protein sequence contains 240 amino acids including a leader sequence of 22 residues and a carboxy-terminal sequence of 23 residues that is replaced in the processed molecule by a glycosyl-phosphatidylinositol anchor attached at serine 195
- Two Ig-related domains are predicted to account for all of the processed sequence and the circular dichroism spectrum shows pure beta-structure
- The amino-terminal domain is V-like, but without a disulphide bond, while the second domain is C-like (C2- SET ) with two disulphide bonds
- The sequence matches particularly well with the extracellular parts of LFA-3 and CD2 antigens and the first two domains of carcinoembryonic antigen and non-specific, cross-reacting antigen
Output (sent_index, trigger,
protein,
sugar,
site):
- 1. glycoprotein, , glycoprotein, -, -
Output(Part-Of) (sent_index,
protein,
site):
- 5. -, sequence
- 8. carcinoembryonic antigen, domains
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):