PMID: 32155444

 

    Legend: Gene, Sites

Title : Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Abstract :

1. The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths
2. Coronavirus spike ( S ) glycoproteins promote entry into cells and are the main target of antibodies
3. We show that SARS-CoV-2  S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2  S and SARS-CoV S bind with similar affinities to human ACE2 , correlating with the efficient spread of SARS-CoV-2 among humans
4. We found that the SARS-CoV-2  S glycoprotein harbors a furin cleavage site at the boundary between the S1/S2 subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs
5. We determined cryo-EM structures of the SARS-CoV-2  S ectodomain trimer, providing a blueprint for the design of vaccines and inhibitors of viral entry
6. Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited SARS-CoV-2 S mediated entry into cells, indicating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
Coronavirus spike	43740568	2
ACE2	59272	3
Spike Glycoprotein	43740568	0
furin	5045	4