PMID: 3886654

 

    Legend: Gene, Sites

Title : Amino acid sequence of the heavy chain of human alpha- factor XIIa (activated Hageman factor )

Abstract :

1. The amino acid sequence of the heavy chain of human alpha- factor XIIa (activated Hageman factor ) was determined by automated Edman degradation using the peptides produced by chemical and enzymatic cleavages of intact factor XII and alpha- factor XIIa
2. Combining this sequence with the previously determined sequence of beta- factor XIIa (Fujikawa, K., and McMullen, B. A. (1983) J. Biol
3. Chem
4. 258, 10924-10933), the complete amino acid sequence of human factor XII has been established
5. The heavy chain of alpha- factor XIIa is composed of 353 amino acid residues containing one Asn-linked and six probable O-linked carbohydrate chains
6. The heavy chain of alpha- factor XIIa appears to contain four different domains including a "kringle," a "growth factor " domain , and the "type I" and "type II" domains of fibronectin
7. The domain organization of factor XII is analogous to those of several fibrinolytic proteins , including tissue plasminogen activator and urokinase , suggesting that factor XII belongs to the same protease subfamily as these two proteins

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 2. factor XIIa, sequence
• 4. factor XII, sequence
• 6. factor, domain
• 6. fibronectin, domain
• 6. fibronectin, domains

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
fibronectin	2335	6