PMID: 6619128

 

    Legend: Gene, Sites

Title : Structures of the O-glycosidically linked oligosaccharides of human IgD

Abstract :
  1. In the previous communication (Mellis, S. J., and Baenziger, J. U. (1983) J. Biol
  2. Chem
  3. 258, 11546-11556), the structures of the oligosaccharides present at the 3 asparagine glycosylation sites of a human IgD myeloma protein were defined
  4. In this communication, we present the structures of the O-glycosidically linked oligosaccharides located in the hinge region of IgD :WAH
  5. Three or four threonine residues and one serine residue in the region bear O-glycosidically linked oligosaccharides
  6. Approximately 50% of these molecules have the structure Gal beta 1 leads to 3 GalNAc which is identical with the structure of the predominant oligosaccharide in the hinge region of human IgA1 myeloma proteins (Baenziger, J. U., and Kornfeld, S. (1974) J. Biol
  7. Chem
  8. 249, 7270-7281)
  9. The remainder of the oligosaccharides contain 1 or 2 residues of N-acetylneuraminic acid and have the structures NeuAc alpha 2 leads to 3 Gal beta 1 leads to 3GalNAc (30%), Gal beta 1 leads to (NeuAc alpha 2 leads to 6)GalNAc (12%), and NeuAc alpha 2 leads to 3Gal beta 1 leads to 3(NeuAc alpha 2 leads to 6)GalNAc (8%)
  10. The sialylated molecules have not been encountered previously on other human immunoglobulin heavy chains
  11. These structures, however, have been described on a number of secreted and membrane glycoproteins
  12. Examination of oligosaccharides isolated from different subregions of the IgD hinge indicated that a specific distribution of the sialylated structures among the glycosylated amino acids of the hinge region is not likely
Output (sent_index, trigger, protein, sugar, site):
  • 0. IgD, , IgD, the O-glycosidically linked oligosaccharides, -
  • 11. glycoproteins, , glycoproteins, -, -
  • 12. sialylated, , -, the sialylated structures, -
  • 3. glycosylation, , protein, -, sites
  • 3. present, , protein, the oligosaccharides, sites
  • 5. bear, , -, O-glycosidically linked oligosaccharides, serine residue
  • 5. bear, , -, O-glycosidically linked oligosaccharides, threonine residues
  • 6. oligosaccharide, , -, the hinge region, region
Output(Part-Of) (sent_index, protein, site):
  • 3. protein, sites
  • 4. IgD, region
  • 6. proteins, region
*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

 

Protein NCBI ID SENTENCE INDEX