PMID: 6689265

 

    Legend: Gene, Sites

Title : Isolation and characterization of the O-glycan chain of the human vitamin-D binding protein

Abstract :

1. On a highly purified preparation, the structure of the carbohydrate chain of the human vitamin D-binding protein was investigated and two genetic forms of this protein were considered ( Gc 2 and Gc 1 proteins )
2. It was found that only the Gc 1 protein ( Gc1a isoform ) was glycosylated, the glycan moiety representing about 1% of the protein
3. The structure of this O-glycosidically linked glycan was determined to be: Neu Ac alpha (2 leads to 3) Gal beta (1 leads to 3) GaINAc alpha (1 leads to 0) Ser (or Thr )
4. A tetrasaccharidic O-glycan with two N-acetylneuraminic residues was also characterized
5. The vitamin D-binding protein is a rare example of a serum protein O-glycosylated only on some genetic forms

Output (sent_index, trigger, protein, sugar, site):

• 0. protein, , vitamin-D binding protein, the O-glycan chain, -
• 1. protein, , vitamin D-binding protein, the carbohydrate chain, -
• 2. glycosylated, , Gc 1 protein, -, -
• 2. glycosylated, , isoform, -, -

Output(Part-Of) (sent_index, protein, site):

• 3. Ac alpha, Ser

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
Gc 1 protein	10562	2
Gc 1 proteins	10562	1
vitamin-D binding protein	2638	0
vitamin D-binding protein	2638	1,5