PMID: 7309709

 

    Legend: Gene, Sites

Title : Studies on the structures of the carbohydrate moiety of human prothrombin

Abstract :

1. Human prothrombin contains three asparagine-linked sugar chains in one molecule
2. The sugar chains were quantitatively liberated as radioactive oligosaccharides from the polypeptide moiety by hydrazinolysis followed by N-acetylation and Nab3H4 reduction
3. All of the oligosaccharides contain N-acetylneuraminic acid
4. The neutral oligosaccharides obtained from all acidic oligosaccharides by sialidase digestion are identical
5. By the combination of sequential exoglycosidase digestion and methylation analysis, the structures of the asparagine-linked sugar chains of human prothrombin were confirmed to be as follows: (sequence in text)

Output (sent_index, trigger, protein, sugar, site):

• 0. prothrombin, , prothrombin, the carbohydrate moiety, -
• 1. asparagine-linked, , -, three asparagine-linked sugar chains, asparagine
• 1. contains, , Human prothrombin, three asparagine-linked sugar chains, -
• 5. asparagine-linked, , -, the asparagine-linked sugar chains, asparagine
• 5. prothrombin, , prothrombin, the asparagine-linked sugar chains, -

Output(Part-Of) (sent_index, protein, site):

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
Human prothrombin	2147	1
prothrombin	2147	0,5