PMID: 7477400

 

    Legend: Gene, Sites

Title : The structure of an intermediate in class II MHC maturation: CLIP bound to HLA- DR3

Abstract :

1. A complex between HLA- DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined
2. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain- DR3 and antigenic peptide- DR3 complexes
3. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins
4. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM

Output (sent_index, trigger, protein, sugar, site):

• 3. glycoproteins, , glycoproteins, -, -

Output(Part-Of) (sent_index, protein, site):

• 3. CLIP, fragment

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
DR3	8718	0,1,2,3
CLIP	6249	0,1,3