PMID: 8978667

 

    Legend: Gene, Sites

Title : Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge

Abstract :

1. TWIK-1 is a new type of K+ channel with two P domains and is abundantly expressed in human heart and brain
2. Here we show that TWIK-1 subunits can self-associate to give dimers containing an inter chain disulfide bridge
3. This assembly involves a 34 amino acid domain that is localized to the extracellular M1P1 linker loop
4. Cysteine 69 which is part of this interacting domain is implicated in the formation of the disulfide bond
5. Replacing this cysteine with a serine residue results in the loss of functional K+ channel expression
6. This is the first example of a covalent association of functional subunits in voltage-sensitive channels via a disulfide bridge

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX