Title :
Cig30 , a mouse member of a novel membrane
protein gene family, is involved in the recruitment of brown adipose tissue
Abstract :
- We have identified a previously uncharacterized gene that is implicated in the thermogenic function of brown adipose tissue of mice
- This gene, termed Cig30 , is the first mammalian member of a novel gene family comprising several nematode and yeast genes, such as SUR4 and FEN1 , mutation of which is associated with highly pleiotropic phenotypes
- It codes for a 30-kDa plasma membrane glycoprotein with five putative transmembrane domains
- The Cig30 mRNA was readily detected only in brown fat and liver
- When animals were exposed to a 3-day cold stress, the Cig30 expression was selectively elevated in brown fat more than 200-fold
- Similar increases were brought about in two other conditions of brown fat recruitment, namely during perinatal development and after cafeteria diet
- The magnitude of Cig30 mRNA induction in the cold could be mimicked by chronic norepinephrine treatment in vivo
- However, in primary cultures of brown adipocytes, a synergistic action of norepinephrine and dexamethasone was required for full expression of the gene, indicating that both catecholamines and glucocorticoids are required for the induction of Cig30
- We propose that the CIG30 protein is involved in a pathway connected with brown fat hyperplasia
Output (sent_index, trigger,
protein,
sugar,
site):
- 3. glycoprotein, , glycoprotein, -, -
Output(Part-Of) (sent_index,
protein,
site):
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):