Title : Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites
Abstract :
- The primary structure of murine betaglycan, also known as transforming growth factor beta (TGF-beta) type III receptor , was deduced from the nucleotide sequence of a cDNA clone isolated from a heart library
- Murine betaglycan is a single spanning membrane polypeptide of 850 amino acids which is highly similar to betaglycan of other species
- Transfection of this cDNA into COS1 cells resulted in the expression of a membrane proteoglycan that binds TGF-beta and is recognized by antibodies raised against rat betaglycan
- COS1 cells transfected with the double mutant Ser533Ala; Ser544Ala of the murine betaglycan cDNA produced a TGF-beta type III receptor devoid of glycosaminoglycan chains
Output (sent_index, trigger,
protein,
sugar,
site):
Output(Part-Of) (sent_index,
protein,
site):
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):