PMID: PMC4739677-1-12

 

    Legend: Gene, Sites

Title : Inter-α-trypsin Inhibitor Heavy Chain H4

Abstract :
  1. For the protease inhibitor inter-alpha-trypsin inhibitor heavy chain H4 two O-glycosylation sites/regions, Ser640 and Thr722/723 have been described in literature (58, 65)
  2. In agreement with recent findings by Chandler et al., Ser640 was found to be O-glycosylated
  3. The O-glycopeptide 639AFPR644 (m/z 660.722+) harbors two potential O-glycosylation sites and the occupied site could be clearly inferred from the ETD spectra by the presence of a signal at m/z 490.221+, corresponding to a z+14 ion (supplemental Fig
  4. S5)
  5. In contrast to Chandler et al., but in agreement with Halim et al., ETD data of the O-glycopeptide 722QTPAPIQAPS733 (m/z 623.273+) suggested the occupancy of the sites Thr722/723 (58, 65) (supplemental Fig
  6. S5)
  7. Unfortunately, none of the two potential O-glycosylation sites could be clearly ruled out by the detected fragment ions
  8. Both sites/regions Ser640 and Thr722/723 were decorated with a monosialylated T-antigen
  9. This contrasts previous findings by Chandler et al. who also observed a disialylated T-antigen on S640
Output (sent_index, trigger, protein, sugar, site):
  • 2. O-glycosylated, , -, -, Ser640
  • 3. O-glycopeptide, , -, -, O-glycopeptide
  • 3. O-glycosylation, , -, -, sites
  • 5. O-glycopeptide, , -, -, O-glycopeptide
  • 5. occupancy, , -, -, sites
  • 7. O-glycosylation, , -, -, sites
Output(Part-Of) (sent_index, protein, site):
  • 1. inter-alpha-trypsin inhibitor heavy chain H4, sites/regions, Ser640
*Output_Site_Fusion* (sent_index, protein, sugar, site):
  • 2. inter-alpha-trypsin inhibitor heavy chain H4, -, Ser640

 

 

Protein NCBI ID SENTENCE INDEX