PMID: PMC4739677-1-14

 

    Legend: Gene, Sites

Title : τ-Tubulin Kinase 2

Abstract :
  1. The τ-tubulin kinase 2 2 (TTBK2 ) phosphorylates τ and tubulin, preferably in the nervous system
  2. Aberrant TTBK2 activity was linked to the progression of the Alzheimer's disease (70, 71)
  3. The protein resides primarily in the cytosol; however, Böhm et al. could also detect TTBK2 in a secreted form in human tears (72, 73)
  4. Hitherto, no glycosylation of this protein has been described
  5. CID-MS3 as well as ETD spectra of the O-glycopeptide 814KDHSATEPL823 \+HexNAc1Hex1NeuAc1 (m/z 877.822+), though, suggest the O-glycosylation of Thr820
  6. ETD fragment ions at m/z 485.221+, 557.431+, and 1098.631+, corresponding to c4, c+15, and z4 ions, allowed discerning the exact glycosylation site
  7. As TTBK2 is involved in ciliogenesis (74, 75), a process which requires the vesicle transport from the Golgi to the basal bodies and cilia, we speculate that TTBK2 might become O-glycosylated during this process
Output (sent_index, trigger, protein, sugar, site):
  • 4. glycosylation, , protein, -, -
  • 5. O-glycopeptide, , -, the O-glycopeptide 814KDHSATEPL823 +HexNAc1Hex1NeuAc1, O-glycopeptide
  • 5. O-glycosylation, , -, -, Thr820
  • 6. glycosylation, , -, -, site
Output(Part-Of) (sent_index, protein, site):
*Output_Site_Fusion* (sent_index, protein, sugar, site):
  • 5. 2 (TTBK2, -, Thr820

 

 

Protein NCBI ID SENTENCE INDEX