PMID: PMC6145689-1-fig4

 

    Legend: Gene, Sites

Title : Intact N-glycopeptides as candidate biomarkers for PCa detection (A) Principal component analysis (PCA) using a panel of 56 N-glycopeptides with aberrant levels in PCa relative to BHP (Table 1)

Abstract :
  1. (B) PCA using a set of 27 deamidated peptides covering the same glycosylation sites as identified with intact N-glycopeptide analysis (Table 1)
  2. (C) PCA using a set of non-modified peptides from the glycoproteins that carried the panel of differentially abundant intact N-glycopeptides (Table 1)
  3. (D) Clustering of intact N-glycopeptides displaying altered expression in PCa is shown as a heat map after applying Euclidean distance
  4. (E) ROC curve analysis was performed based on partial least squares discriminant analysis (PLS-DA) using the panel of PCa-associated intact N-glycopeptides (Table 1)
  5. (F) Network analysis using the list of glycoproteins which carried the differentially abundant intact N-glycopeptides (Table 1)
  6. Significant enriched KEGG pathway complement and coagulation cascades (FDR < 0.05) and regulation of immune system response (Gene Ontology, FDR < 0.05) are colored in blue and red, respectively
Output (sent_index, trigger, protein, sugar, site):
  • 0. N-glycopeptides, , -, -, N-glycopeptides
  • 1. N-glycopeptide, , -, -, N-glycopeptide
  • 1. glycosylation, , -, -, sites
  • 2. N-glycopeptides, , -, -, N-glycopeptides
  • 2. glycoproteins, , glycoproteins, -, -
  • 3. N-glycopeptides, , -, -, N-glycopeptides
  • 4. N-glycopeptides, , -, -, N-glycopeptides
  • 5. N-glycopeptides, , -, -, N-glycopeptides
  • 5. glycoproteins, , glycoproteins, -, -
Output(Part-Of) (sent_index, protein, site):
  • 2. glycoproteins, peptides
*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

 

Protein NCBI ID SENTENCE INDEX