Title : Intact
N-glycopeptides as candidate biomarkers for PCa detection (A) Principal component analysis (PCA) using a panel of 56
N-glycopeptides with aberrant levels in PCa relative to BHP (Table 1)
Abstract :
- (B) PCA using a set of 27 deamidated peptides covering the same glycosylation sites as identified with intact N-glycopeptide analysis (Table 1)
- (C) PCA using a set of non-modified peptides from the glycoproteins that carried the panel of differentially abundant intact N-glycopeptides (Table 1)
- (D) Clustering of intact N-glycopeptides displaying altered expression in PCa is shown as a heat map after applying Euclidean distance
- (E) ROC curve analysis was performed based on partial least squares discriminant analysis (PLS-DA) using the panel of PCa-associated intact N-glycopeptides (Table 1)
- (F) Network analysis using the list of glycoproteins which carried the differentially abundant intact N-glycopeptides (Table 1)
- Significant enriched KEGG pathway complement and coagulation cascades (FDR < 0.05) and regulation of immune system response (Gene Ontology, FDR < 0.05) are colored in blue and red, respectively
Output (sent_index, trigger,
protein,
sugar,
site):
- 0. N-glycopeptides, , -, -, N-glycopeptides
- 1. N-glycopeptide, , -, -, N-glycopeptide
- 1. glycosylation, , -, -, sites
- 2. N-glycopeptides, , -, -, N-glycopeptides
- 2. glycoproteins, , glycoproteins, -, -
- 3. N-glycopeptides, , -, -, N-glycopeptides
- 4. N-glycopeptides, , -, -, N-glycopeptides
- 5. N-glycopeptides, , -, -, N-glycopeptides
- 5. glycoproteins, , glycoproteins, -, -
Output(Part-Of) (sent_index,
protein,
site):
- 2. glycoproteins, peptides
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):