PMID: PMC6243375-1-fig3

 

    Legend: Gene, Sites

Title : Comparative analysis of the O‐linked glycoproteome of normal and tumor‐derived kidney tissue Data processing steps in label‐free quantification to identify differential glycoproteins between tumor and normal kidney tissues

Abstract :
  1. Volcano plot of differentially expressed O‐linked glycoproteins between tumor and normal tissues
  2. A total of 592 glycoproteins are plotted in the Volcano plot according to their fold change (log2) and number of differential PSM between cancer and normal (log10)
  3. Red and green dots indicate significantly upregulated and downregulated proteins , respectively
  4. Extensive addition of O‐linked glycans at sites covering versican core protein ( VCAN ) (upper panel) and aggrecan core protein ( ACAN ) (lower panel)
  5. Fold change for specific site between tumor and normal was showed as connected dots in red
  6. Sites only detected in tumor or normal were assigned two‐ or 0.5‐fold change, respectively
  7. Red asterisks indicate sites with the highest PSM number divergent between tumor and normal tissues
  8. The 56 O‐linked glycoproteins with significant change between tumor and normal
Output (sent_index, trigger, protein, sugar, site):
  • 0. glycoproteins, , glycoproteins, -, -
  • 1. glycoproteins, , glycoproteins, -, -
  • 2. glycoproteins, , glycoproteins, -, -
  • 8. glycoproteins, , glycoproteins, -, -
Output(Part-Of) (sent_index, protein, site):
*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

 

Protein NCBI ID SENTENCE INDEX